Can You Combine Fillers, Skinboosters, and Polynucleotides?
Many patients ask me, “Can I do fillers and skinboosters together?” or “Should I add polynucleotides too?”
The short answer is yes — when combined thoughtfully, these treatments can complement each other beautifully. But they each serve a different purpose. The key lies in understanding what each one does for your skin, and when to use them.
Different Tools, Different Purposes
1. Fillers – Structure and Shape
Dermal fillers are designed to restore volume, contour, or definition. Most are made from hyaluronic acid (HA) and placed deeper beneath the skin to support facial structure.
They help:
- Replace age-related volume loss
- Lift and contour cheeks or jawline
- Smooth deeper folds
- Balance facial proportions
Think of fillers as the architecture beneath your skin — providing shape and support where needed.
2. Skinboosters – Hydration and Glow
Skinboosters are also HA-based, but that’s where the similarity with fillers ends.
Instead of adding volume, they’re soft, fluid formulations injected very superficially to improve hydration, texture, and radiance.
They help:
- Smooth fine lines
- Improve elasticity
- Boost luminosity
- Strengthen the skin barrier
If fillers are structure, skinboosters are the light and texture on the surface.
3. Polynucleotides (PN) – Repair and Regeneration
Polynucleotides are bio-revitalising molecules derived from salmon or trout DNA fragments that stimulate tissue repair, fibroblast activation, and collagen synthesis.
They don’t fill or plump. Instead, they improve the quality of the skin at a cellular level — enhancing elasticity, hydration, and healing.
They help:
- Calm inflammation
- Improve thin, crepey skin
- Reduce post-procedure redness
- Support long-term skin regeneration
Think of them as nutrients for your skin cells, helping your skin behave like its younger self.
Why Combination Treatments Work So Well
Our skin doesn’t age in one layer — it changes in structure, texture, and cellular function all at once.
That’s why combining treatments can deliver more complete, natural results:
| Treatment | Focus | Layer of Action | Result |
|---|---|---|---|
| Filler | Volume & structure | Deep (subdermal) | Lift & contour |
| Skinbooster | Hydration & radiance | Superficial (intradermal) | Dewy, smooth skin |
| Polynucleotide | Cellular repair | Mid to superficial dermis | Strengthened, resilient skin |
Together, they address both the foundation and the surface — restoring light, balance, and health across the face.
How We Combine Them
Combination treatments can be done all at once, but in different layers or areas for safety and precision:
- Phase 1: Restore structure with fillers (if needed).
- Phase 2: Rejuvenate with skinboosters and polynucleotides over subsequent weeks.
- Phase 3: Maintain with gentle touch-ups every 6–12 months.
When done this way, each product enhances the other’s effect — without heaviness or risk of lumpiness.
Safety Matters
It’s important to remember that not all products can be mixed or injected together in the same session.
For example, some topical “skinboosters” or economies on the market are not meant for injection and can cause nodules or inflammation if used incorrectly.
Always ensure your treatment plan is tailored to your skin’s condition, anatomy, and timing between procedures.
Final Thoughts
Combining fillers, skinboosters, and polynucleotides isn’t about doing more — it’s about layering care thoughtfully to achieve balanced, natural rejuvenation.
Each has a role to play. When planned with precision, they work in harmony — creating skin that looks refreshed, luminous, and quietly confident.
With care,
Dr. Chia Min Shan
